Ethyl 3-(2-methylphenyl)-3-oxopropanoate

Ethyl 3-(2-methylphenyl)-3-oxopropanoate - Names and Identifiers

Name	ethyl 3-(2-methylphenyl)-3-oxopropanoate
Synonyms	Ethyl o-toluoylacetate 3-OXO-3-O-TOLYLPROPANOATE Ethyl o-methylbenzoylacetate ETHYL (2-METHYLBENZOYL)ACETATE ETHYL 3-OXO-3-O-TOLYLPROPANOATE Ethyl 2-(2-methylbenzoyl)acetate Ethyl 3-(2-methylphenyl)-3-oxopropanoate ethyl 3-(2-methylphenyl)-3-oxopropanoate 3-OXO-3-O-TOLYL-PROPIONIC ACID ETHYL ESTER Benzenepropanoic acid, 2-methyl-beta-oxo-, ethyl ester
CAS	51725-82-7
InChI	InChI=1/C12H14O3/c1-3-15-12(14)8-11(13)10-7-5-4-6-9(10)2/h4-7H,3,8H2,1-2H3

Ethyl 3-(2-methylphenyl)-3-oxopropanoate - Physico-chemical Properties

Molecular Formula	C12H14O3
Molar Mass	206.24
Density	1.069g/mLat 25°C(lit.)
Boling Point	256-257°C(lit.)
Flash Point	>230°F
Vapor Presure	0.00248mmHg at 25°C
Maximum wavelength(λmax)	287nm(MeOH)(lit.)
pKa	10.00±0.46(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	n20/D 1.5255(lit.)

Ethyl 3-(2-methylphenyl)-3-oxopropanoate - Risk and Safety

WGK Germany

Ethyl 3-(2-methylphenyl)-3-oxopropanoate - Introduction

Ethyl 3-(2-methylphenyl)-3-oxopropanoate is an organic compound with the chemical formula C12H14O3. It is a colorless liquid with a benzene scent at room temperature. The main properties of the compound include good solubility, moderate volatility and low toxicity.

ethyl 3-(2-methylphenyl)-3-oxopropanoate is commonly used as a reagent in organic synthesis. It can be used as an intermediate in the synthesis of ketones or aldehydes, and participate in a variety of organic synthesis reactions, such as Mannich reactions, hydroxysulfonamide reactions, etc. Such compounds can also be used to prepare compounds having biological activity.

The method for preparing ethyl 3-(2-methylphenyl)-3-oxopropanoate is by esterifying o-tolylcyclohexanone with glycolic acid. The specific operation process is that o-tolyl cyclohexanone is reacted with excess anhydrous glycolic acid, an acidic catalyst is added, the catalyst is removed by filtration after a period of reaction, and then purified by distillation.

When using or handling ethyl 3-(2-methylphenyl)-3-oxopropanoate, you need to pay attention to some safety information. This compound is slightly irritating and avoids contact with skin and eyes. Wear suitable protective gloves and goggles during operation. In addition, it is also flammable, avoid exposure to open flames and high temperatures, and store in a cool, dry place, away from fire sources.

Last Update：2024-04-10 22:29:15